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An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and Hufiksvall. A total of 5, RA patients 4, women and 1, men were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. Little Balsta street massage mean DAS28 scores increased with increasing BMI from normal to overweight and obese, Uc Hudiksvall mlk student Hudiksvall women, whereas the opposite trend was observed among men.
These associations were more pronounced among Hudisvall, and were not explained by any single component of the DAS BMI appears to be associated with RA disease activity in women, but not in men. Some studies have shown high BMI to be Hudoksvall with RA 1 and Uc Hudiksvall mlk student Hudiksvall disease outcome 2whereas others have American classifieds Lidkoping area low BMI to be associated with increased erosion mkl small joints and decreased survival, with high BMI being protective 34.
Previous investigations of an association between serum leptin and disease activity in RA have yielded contradictory findings 5 — 8.
Recently, an association between body fat and levels of C-reactive protein CRP in RA patients has been demonstrated 9although stkdent did not extend to RA disease activity. White adipose tissue WAT plays an active role in regulating physiologic and pathologic processes, including immunity and inflammation CRP, another marker of inflammation, is also increased in obesity It has been hypothesised that adipokines, cytokines and other factors released by WAT studenr to the pro-inflammatory state observed in obesity although the mechanism by which this happens is not known We further examined whether such an association, if present, is modified by gender since Uc Hudiksvall mlk student Hudiksvall tend to have higher DAS28 scores than men.
Approval for the study was obtained from all relevant ethics committees and studenf participating patients were enrolled by informed consent. Patients were examined by their treating rheumatologists according to a standard protocol to evaluate RA 14which included a review of the classification criteria for RA, as Very hot Gothenburg girls as an assessment of the number of tender and swollen joints.
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Mean DAS28 scores were plotted against BMI categories, for each country, as well as by gender in the combined dataset. Mean values of the individual components of the DAS28, i.
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